The Indian Removal Act of 1830 led to the forced relocation of thousands of Indians from their native areas to reservations, primarily in what’s now Oklahoma. Some tribes fought that move.
In particular, the Seminole of Florida were quick to take up arms. They’d already fought a war against the U.S. in 1817-1818. And while the Seminole lost, they continued to defend their territory in the Second Seminole War between 1835 and 1842. Many of the Indians did relocate, but still others continued fighting until near the start of the Civil War.