It was in March of 1822 that the now-famous advertisement appeared in the Missouri Republican: TO ENTERPRISING YOUNG MEN.  The subscriber wishes to engage one hundred young men to ascend the Missouri River to its source, there to be employed for one, two, or three years. For particulars, inquire of Major Andrew Henry, near the lead mines in the county of Washington, who will ascend with, and command, the party; or of the subscriber near St. Louis.   General William Ashley and Major Andrew H


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